For laboratory research use only Not for human or animal consumption.
Weight-loss research · Retatrutide (LY3437943)

One peptide. Three metabolic receptors.

Retatrutide is an investigational GIP / GLP-1 / glucagon triple receptor agonist, supplied for laboratory research into appetite signalling, energy expenditure and body composition. Every lot ships with an independent, lot-matched CoA.

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RUO · in-vitro only Research compound. Not for human or animal consumption.
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Research use only · not for human consumption Independent CoA on every lot 99.32% avg HPLC purity Ice-pack shipping · 2–3 days Statements show “AB RSCH” Failed-CoA lot replacement 284 independent assays / month
Research use only · not for human consumption Independent CoA on every lot 99.32% avg HPLC purity Ice-pack shipping · 2–3 days Statements show “AB RSCH” Failed-CoA lot replacement 284 independent assays / month
What the research shows

The most-watched compound in metabolic research.

Published human trials describe what a triple agonist does in a clinical setting. We supply the compound, and the proof of what is in the vial.

0.0%
Mean body-weight reduction

Reported at 48 weeks in the 12 mg arm of the published phase 2 trial, against 2.1% on placebo.

Jastreboff et al., NEJM 2023
0
Receptors, one molecule

GIP, GLP-1 and glucagon receptor activity studied together for additive effects on appetite, insulin signalling and energy expenditure.

Coskun et al., Cell Metabolism 2022
Phase 3
Trials under way

The TRIUMPH programme is studying retatrutide in obesity, type 2 diabetes, knee osteoarthritis and obstructive sleep apnoea.

ClinicalTrials.gov · TRIUMPH-1 to -4

Figures describe published human clinical research on the compound. Apex Biohacks supplies {{ productName }} for in-vitro laboratory research only and makes no claims about its use.

How it's studied

Three receptors, three signals.

Semaglutide works on one. Tirzepatide on two. Retatrutide is the first to be studied across all three incretin-axis receptors at once.

GLP-1R01
Appetite and gastric emptying

The pathway semaglutide acts on. Studied for satiety signalling and slower gastric transit.

GIPR02
Insulin signalling and adipose handling

The second receptor behind tirzepatide. Studied for glucose-dependent insulin release and fat-tissue metabolism.

GCGR03
Hepatic energy expenditure

The glucagon receptor is what sets retatrutide apart. Studied for lipid oxidation and raised energy expenditure.

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For laboratory research use only {{ productName }} is sold for in-vitro research purposes only. It is not a drug, food, cosmetic or supplement. Not for human or animal consumption. By ordering you confirm you are a qualified researcher.
CoA includedLot-matched HPLC + mass-spec
Ice-pack shippingUSPS / FedEx · 2–3 days
Discreet billingStatements show “AB RSCH”
Lot replacementIf a lot fails your assay
Retatrutide + Bacteriostatic water
Reta + Bac water bundle 10 mg Retatrutide + 10 ml bacteriostatic water
€124.20€138 · save €13.80
View bundle
Retatrutide research vial
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The receipt is the product

We don't ask you to trust us. We ship the proof.

Every lot goes to Brown Biology Lab, an ISO-17025-accredited, A2LA-certified independent facility, before it leaves our floor. The CoA in your box is the one anyone can pull from the public library.

Six tests per lotHPLC purity, MALDI-TOF mass, endotoxin (LAL), bioburden, appearance and moisture, sequence verification.
Public, lot-matchedScan the lot on your vial and pull the same certificate from the CoA library. No private reports.
Replaced if it fails your assayRun your own test. If the lot doesn't match its certificate, send us the data and we replace it.
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Procurement-specific question? Email research@apexbiohacks.com — we typically reply the same business day.

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Often researched together
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